Wednesday, April 13, 2016
Seizure Meds
Seizure meds:
1st Line for prolonged seizures and status epilepticus: Benzos, esp. Clonazepam: GABA chlorine channel allosteric inducers, incr. frequency of chlorine channel opening, (as opposed to barbiturates which increase duration) Mnemonic: bEnzos increase Freq, while bArbiturates increase Duration. E comes after A in the alphabet and F comes after D; or Ben pees Frequently, but Barb takes a long time in the bathroom.
Ethosuximide: Absence only, Mechanism is calcium channel blockade
All others are sodium channel blockers:
Valproate: Absense + T-clonic
Phenytoin: T-Clonic + Status epilepticus
Phenobarbitol: T-Clonic
1st Line for prolonged seizures and status epilepticus: Benzos, esp. Clonazepam: GABA chlorine channel allosteric inducers, incr. frequency of chlorine channel opening, (as opposed to barbiturates which increase duration) Mnemonic: bEnzos increase Freq, while bArbiturates increase Duration. E comes after A in the alphabet and F comes after D; or Ben pees Frequently, but Barb takes a long time in the bathroom.
Ethosuximide: Absence only, Mechanism is calcium channel blockade
All others are sodium channel blockers:
Valproate: Absense + T-clonic
Phenytoin: T-Clonic + Status epilepticus
Phenobarbitol: T-Clonic
Monday, April 11, 2016
Tuesday, April 5, 2016
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