Saturday, October 22, 2016

Onco and Anti-oncogenes

Gene Function Syndrome/Disease
n-myc oncogene neuroblastoma, small cell carcinoma of lung
L-myc oncogene Small Cell Lung Cancer
c-myc oncogene Burkitt's Lymphoma (Chromosome 8)
ABL oncogene CML and ALL
BCR-ABL t(9;22) oncogene CML or ALL
BRAF oncogene Melanoma
BCL-2 oncogene Follicular Lymphoma with t(14;18)
SIS oncogene Astrocytoma, Hepatocellular Carcinoma
HER-1 oncogene Squamous Cell Carcinoma
HER-2 oncogene Breast Cancer, Ovarian Cancer
KRAS oncogene Lung Cancer, Colon Cancer, Pancreatic Cancer
HRAS oncogene Renal Cell Cancer, Bladder Cancer
TGFA SIS oncogene Astrocytoma, Hepatocellular Carcinoma
APC/β Catenin anti-oncogene Stomach Cancer, Colon, Pancreatic Cancer, Familial Adenomatous Polyposis
DCC anti-oncogene Colon Cancer
NF1 anti-oncogene Neuroblastoma, Neurofibromatosis Type 1, Sarcoma
VHL anti-oncogene Von Hippel Lindau Syndrome, Renal Cell Cancer
WT-1 anti-oncogene Wilms Tumor
BRCA1, BRCA2 anti-oncogene Breast Cancer, Ovarian Cancer
RB anti-oncogene, suppresses G1 to S inactivated in many cancers
TP53 anti-oncogene p53 "guardian of the cell" inactivated in many cancers

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