Tuesday, January 24, 2017

Candida albicans



NOTE: During OBGYN rotation, told NOT to use fluconazole for candidal vaginitis, but Gynazole (butoconazole) or Terazol (terconazole) vaginal creams, due to resistance.

Dimorphic: mold in heat/yeast in cold EXCEPTION!
Immunocompromised at greater risk
Catalase positive (Cat)
Forms germ tubes=true hyphae at 37 degrees F. (37 different flavors with germ-tube-mold looking cones)
Diaper rash (Crying baby)
Rx for oral/esophageal: Nystatin (binds ergosterol) (Play Nyce!)
Rx for amphotericin (binds ergosterol) resistance: caspofungin (cell-wall)
At 20 degrees, yeast form with pseudohyphae (Snowballs with pseudohyphae-looking plant)
Inhaled steroids are risk factor for oral infection (boy has inhaler)
Esophageal candidiasis diagnostic for AIDS
White fungal patches CAN be scraped off (unlike EBV-caused hairy leukoplakia) (KOH salt for shovelling, scraping snow)
Dx with KOH preparation, microscopy (look for pseudohyphae)
Antibiotics, birth control, diabetes risk factors for vaginal candidiasis (vaginal candidiasis)
Rx for local infections: -conazoles (pine cones)
pH remains normal below 4 with vaginal candidiasis (park open til 4pm) whereas with Gardnerella, it goes above 4.
At risk of oral/esophageal candida when CD4 count is < 100 (slide with white snow, 100lb wt limit)
Candidal endocarditis on tricuspid valves for IV drug users (Hearts on the 3 rooftops of the playground)


1 comment:

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