Tuesday, January 24, 2017

Plasmodium




Blood stain and Giemsa stain to see merozoites in RBCs
Anopheles mosquitos carry sporozoites
Sporozoites mature to trophozoites in liver
Schizont develops from trophozoites, splits into merozoites, bursts hepatocytes, infects RBCs
Ring form of immature schizont in RBCs
Merozoites can form gametocytes, these reinfect mosquitos
Vivax and ovale spp:
----Hypnozoites in hepatocytes
----Tertian (48 hr) fever cycle
----Rx: primaquinone
----Rx: chloroquine
----Rx for chloroquine resistant: Mefloquine
Plasmodium malariae:
----Quartan (72 hr) fever cycle
----Rx: chloroquine
----Rx for chloroquine resistant: Atovaquone and proguanil
Plasmodium falciparum:
----Parasitized RBCs occlude blood vessels to kidneys and lungs
----Cerebral malaria
----Sickle cell disease is protective
----Rx: artemisins and quinidine
----Side effect of quinidine is cynchonism: tinnitus, deafness, photophobia
----Artesunate and Quinidine delivered IV for severe infection

4 comments:

  1. HSV1 & HSV2 Negative.
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