Blood stain and Giemsa stain to see merozoites in RBCs |
Anopheles mosquitos carry sporozoites |
Sporozoites mature to trophozoites in liver |
Schizont develops from trophozoites, splits into merozoites, bursts hepatocytes, infects RBCs |
Ring form of immature schizont in RBCs |
Merozoites can form gametocytes, these reinfect mosquitos |
Vivax and ovale spp: |
----Hypnozoites in hepatocytes |
----Tertian (48 hr) fever cycle |
----Rx: primaquinone |
----Rx: chloroquine |
----Rx for chloroquine resistant: Mefloquine |
Plasmodium malariae: |
----Quartan (72 hr) fever cycle |
----Rx: chloroquine |
----Rx for chloroquine resistant: Atovaquone and proguanil |
Plasmodium falciparum: |
----Parasitized RBCs occlude blood vessels to kidneys and lungs |
----Cerebral malaria |
----Sickle cell disease is protective |
----Rx: artemisins and quinidine |
----Side effect of quinidine is cynchonism: tinnitus, deafness, photophobia |
----Artesunate and Quinidine delivered IV for severe infection |
Tuesday, January 24, 2017
Plasmodium
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HSV1 & HSV2 Negative.
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