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Cause: Clindamycin kills normal gut flora (although any chronic Abx can cause) | ||
Diarrhea | ||
Gram Positive Obligate anaerobe | ||
Exotoxin A | ||
Targets brush boarder enzymes | ||
Watery diarrhea | ||
Exotoxin B | ||
Pseudomembrane formation | ||
Depolymerization of actin filaments | ||
Anaerobic | ||
Dx: Assay to detect toxin in stool | ||
Rx: Oral vancomycin | ||
Rx: Metronidazole | Commonly C. diff |
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