| Cause: Clindamycin kills normal gut flora (although any chronic Abx can cause) | ||
| Diarrhea | ||
| Gram Positive Obligate anaerobe | ||
| Exotoxin A | ||
| Targets brush boarder enzymes | ||
| Watery diarrhea | ||
| Exotoxin B | ||
| Pseudomembrane formation | ||
| Depolymerization of actin filaments | ||
| Anaerobic | ||
| Dx: Assay to detect toxin in stool | ||
| Rx: Oral vancomycin | ||
| Rx: Metronidazole | Commonly C. diff | |
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