| Gram negative diplococci | |
| Encapsulated: A,B,C,D: 4 capsules | |
| Vaccines to all except capsule B | |
| IgA Protease: cleaves at hinge region | |
| Transmission: college campuses | |
| Colonizes nasopharynx first | |
| LOS envelope proteins cause inflammatory response | |
| Leaky capillaries | |
| Hypovolemia and Shock | |
| Waterhouse-Friderichsen Syndrome: Adrenal hemorrhage | |
| Sickle cell susceptibility | |
| Petichial rash from thrombocytopenia | |
| Risk of DIC | |
| Dx: Ferments both maltose and glucose | |
| Rx: Ceftriaxone | |
| Rifampin prophylaxis for close contacts | |
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